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Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects.
MedLine Citation:
PMID:  23289749     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Hypertension is characterized by microvascular remodeling resulting in increased wall/lumen ratio and elevated microvascular stiffness. Aiming to transform the measurement of macrovascular stiffness into a microvascular environment we introduce a non-invasive method to assess retinal pulse wave velocity (rPWV). rPWV alterations in early hypertension are investigated in detail. The developed methodology is compared with its possible computational alternatives. METHODS: Time dependent alterations of retinal arterial diameter were assessed non-invasively by the Dynamic Vessel Analyzer in 65 male normoalbuminuric normotensive to mildly hypertensive subjects (age: 28.7±6.0 years). rPWV was computed using three different methods. 'Method1' used filtration at heart rate (HR), 'Method2' filtered at higher HR multiples, 'Method3' used additionally linear fit for data averaging. RESULTS: 'Method2' and 'Method3' applying filtration at high HR multiples showed strong associations with systolic BP throughout the cohort (r=0.49, r=0.63, P<0.001). Based on the highest association 'Method3' was proposed to characterize rPWV. Hypertensive patients showed higher rPWV (1243±694 units/second) than subjects with high-normal BP (786±486 units/second, P<0.01) or normotensive subjects (442±148 units/second, P<0.001). CONCLUSIONS: rPWV demonstrated a strong association with BP and can discriminate between optimal, high-normal and mildly hypertensive BP values. rPWV may add detailed insights to early microvascular pathophysiology, potentially beyond microalbuminuria. © 2013 John Wiley & Sons Ltd.
Authors:
Konstantin Kotliar; Henner Hanssen; Karla Eberhardt; Walthard Vilser; Christoph Schmaderer; Martin Halle; Uwe Heemann; Marcus Baumann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
Affiliation:
Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany; Institute of Micro Technology and Medical Device Technology, Technische Universität München, Boltzmannstr. 15, 85748, Garching, Germany.
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