| Retinal progenitor cells, differentiation, and barriers to cell cycle reentry. | |
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MedLine Citation:
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PMID: 20959166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurogenesis in the retina occurs via the coordination of proliferation, cell cycle exit and differentiation of retinal progenitor cells. Until recently, it was widely assumed that once a retinal progenitor cell produced a postmitotic neuron, there was no possibility for cell-cycle re-entry. However, recent studies have shown that mature differentiated horizontal neurons with reduced Rb pathway function can re-enter the cell cycle and proliferate while maintaining their differentiated features. This chapter will explore the molecular and cellular mechanisms that help to keep differentiated retinal neurons and glia postmitotic. We propose that there are cell-type specific barriers to cell-cycle re-entry by differentiated neurons and these may include apoptosis, chromatin/epigenetics mechanisms, cellular morphology and/or metabolic demands that are distinct across cell populations. Our data suggest that differentiated neurons span a continuum of cellular properties related to their ability to re-enter the cell cycle and undergo cytokinesis while maintaining their differentiated features. A deeper understanding of these processes may allow us to begin to explain the cell type specificity of neuronal cell death and tumor susceptibility. For example, neurons that have more barriers to cell-cycle re-entry may be less likely to form tumors but more likely to undergo degeneration. Conversely, neurons that have fewer barriers to cell-cycle re-entry may be more likely to form tumors but less likely to undergo degeneration. |
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Authors:
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Denise M Davis; Michael A Dyer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current topics in developmental biology Volume: 93 ISSN: 1557-8933 ISO Abbreviation: Curr. Top. Dev. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0163114 Medline TA: Curr Top Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 175-88 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology* Cell Death / physiology Cell Differentiation / physiology* Cell Proliferation Chromatin Epigenesis, Genetic Neurons / cytology Retina / cytology* Stem Cells / cytology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chromatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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