| Retinal perfusion response to a slow multifocal M-sequence flicker stimulation. | |
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MedLine Citation:
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PMID: 16020983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess, if a slow multifocal stimulus (mfS) can provoke a perfusion response that can be measured with the Retinal Vessel Analyzer (RVA). METHODS: Seventeen eyes were examined. Pupils were dilated. A 120-second baseline recording was obtained with the RVA. The subject then turned to view an mfS for 56 s. The mfS consisted of 103 hexagons flickering according to an m-sequence with a stimulus base interval of 53.3 ms (L(max) = 100 cd/m(2), L(min) < 1 cd/m(2)). Immediately thereafter, the subject turned to the RVA, where measurements were resumed as soon as the same retinal vessel was targeted and continued for 104 s. Stimulation and recording was repeated twice. The diameter of a retinal vein and artery was measured for a length of at least 1 mm. The maximum vessel response was obtained by linear interpolation of the measured response within the 20 s following mfS. RESULTS: On average, veins dilated by 6.8% and arteries by 7% following mfS (p > 0.005). Such a dilatation could be observed in 9 veins and 7 arteries. Three venous and 2 arterial measurements did not show a dilatation following mfS. However, 13 of 34 measurements could not be analyzed due to signal problems or because the time from the end of mfS and the uptake of measurement exceeded 20 s. CONCLUSION: This slow multifocal ERG stimulus results in a dilatation of arteries and veins that can be measured with the RVA. Coupling an mfS to the RVA has the potential to topographically map changes in retinal perfusion in relation to the respective retinal area stimulated. When implementing the mfS into the RVA setup in order not to lose time due to the refixation in the RVA following mfS, one is required to take the transient nature of this perfusion change into consideration. |
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Authors:
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Anja M Palmowski-Wolfe; Walthard Vilser; Ulrich Laack; Dieter Muller; Klaus W Ruprecht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-07-14 |
Journal Detail:
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Title: Ophthalmic research Volume: 37 ISSN: 0030-3747 ISO Abbreviation: Ophthalmic Res. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 250-4 Citation Subset: IM |
Affiliation:
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University Eye Hospital, Basel, Switzerland. PalmowskiA@uhbs.ch |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diagnostic Techniques, Ophthalmological Glaucoma, Open-Angle / physiopathology* Humans Middle Aged Muscle, Smooth, Vascular / physiopathology Photic Stimulation Pilot Projects Retinal Artery / physiopathology*, radiation effects Retinal Vein / physiopathology*, radiation effects Vasodilation / radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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