| Retinal oxygen saturation is altered in diabetic retinopathy. | |
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MedLine Citation:
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PMID: 22080478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AimRetinal oxygen metabolism is thought to be affected in diabetic retinopathy. The aim of this study was to test whether retinal vessel oxygen saturation is different in patients with diabetic retinopathy from that in healthy controls.MethodsThe retinal oximeter is based on a fundus camera. It estimates retinal vessel oxygen saturation from light absorbance at 586 nm and 605 nm. Retinal vessel oxygen saturation was measured in one major temporal retinal arteriole and venule in healthy volunteers and in patients with diabetic retinopathy.ResultsOxygen saturation in the retinal arterioles of healthy volunteers was 93±4% and 58±6% in venules (mean±SD, n=31). The corresponding values for all diabetic patients (n=20) were 101±5% and 68±7%. The difference between healthy volunteers and diabetic patients was statistically significant (p<0.001 for arterioles and venules). Three subgroups of diabetic patients (background retinopathy, macular oedema and pre-proliferative/proliferative retinopathy) all had higher saturation values than the healthy volunteers (p<0.05 for arterioles and venules).ConclusionRetinal vessel oxygen saturation is higher in patients with diabetic retinopathy than in healthy controls. Possible explanations include shunting of blood through preferential channels, bypassing non-perfused capillaries in the capillary network. Parts of the retinal tissue may be hypoxic while blood in larger vessels has high oxygen saturation. |
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Authors:
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Sveinn Hakon Hardarson; Einar Stefánsson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-11 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: - ISSN: 1468-2079 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Iceland/Landspítali-University Hospital, Reykjavik, Iceland. |
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