| Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy. | |
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MedLine Citation:
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PMID: 22269030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To investigate the relationship between retinal nerve fibre layer thickness and peripheral neuropathy in patients with Type 2 diabetes, particularly in those who are at higher risk of foot ulceration. Methods: Global and sectoral retinal nerve fibre layer thicknesses were measured at 3.45 mm diameter around the optic nerve head using optical coherence tomography (OCT). The level of neuropathy was assessed in 106 participants (82 with Type 2 diabetes and 24 healthy controls) using the 0-10 neuropathy disability score. Participants were stratified into four neuropathy groups: none (0-2), mild (3-5), moderate (6-8), and severe (9-10). A neuropathy disability score (NDS) ≥ 6 was used to define those at higher risk of foot ulceration. Multivariable regression analysis was performed to assess the effect of neuropathy disability score scores, age, disease duration and retinopathy on RNFL thickness. Results: Inferior (but not global or other sectoral) retinal nerve fibre layer thinning was associated with higher neuropathy disability scores (P = 0.03). The retinal nerve fibre layer was significantly thinner for the group with neuropathy disability scores ≥ 6 in the inferior quadrant (P < 0.005). Age, duration of disease and retinopathy levels did not significantly influence retinal nerve fibre layer thickness. Control participants did not show any significant differences in thickness measurements from the group with diabetes and no neuropathy (P > 0.24 for global and all sectors). Conclusions: Inferior quadrant retinal nerve fibre layer thinning is associated with peripheral neuropathy in patients with Type 2 diabetes, and is more pronounced in those at higher risk of foot ulceration. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
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Authors:
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A M Shahidi; G P Sampson; N Pritchard; K Edwards; D Vagenas; A W Russell; R A Malik; N Efron |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
Affiliation:
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Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Princess Alexandra Hospital School of Medicine, University of Queensland, Woolloongabba, Queensland, Australia Division of Cardiovascular Medicine, University of Manchester, Manchester Central Manchester Foundation Trust, Manchester, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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