| Retinal mass in a case of pediatric myelodysplastic syndrome (refractory anemia with excess of blasts). | |
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MedLine Citation:
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PMID: 20037898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Myelodysplastic syndrome is a rare childhood clonal hematologic disorder characterized by dysplastic hematopoiesis and progression to leukemia. METHODS: Case report. RESULTS: An 8-year-old boy with low-grade fever, easy fatigability, and pallor of 3 months duration showed pancytopenia with 9% circulating blast cells. The bone marrow aspirate revealed striking trilineage dysplasia with 13% of blast cells. Cytogenetic analysis revealed 46, XY, del (20) (q11;q13). The findings were diagnostic of myelodysplastic syndrome with refractory anemia with excess of blasts in accordance with the World Health Organization criteria modified for pediatric age group. Fundus examination revealed a sickle-shaped hanging retinal mass of right eye. Biopsy/aspiration cytology of the retinal mass was not done in this case owing to risk of severe bleeding, a common feature in any hematologic malignancy. The child had been included in pediatric acute myeloid leukemia trials as the parents were not ready for stem cell transplantation, but he died after 3 months due to overwhelming infection. CONCLUSIONS: Myelodysplastic syndrome of childhood may present with retinal mass along with other hematologic features. Biopsy/aspiration cytology of the mass should not be attempted as it may cause intraocular hemorrhage. |
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Authors:
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Biswanath Basu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of ophthalmology Volume: 20 ISSN: 1120-6721 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 618-20 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi - India. basuv3000@yahoo.co.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Refractory, with Excess of Blasts
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diagnosis*,
genetics Child Chromosome Aberrations Cytogenetics Fatal Outcome Gonadal Dysgenesis, 46,XY / genetics Humans Male Myelodysplastic Syndromes / diagnosis*, genetics Retinal Diseases / diagnosis*, genetics |
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