Document Detail

Retinal hemodynamic effects of antioxidant supplementation in an endotoxin-induced model of oxidative stress in humans.
MedLine Citation:
PMID:  24576874     Owner:  NLM     Status:  Publisher    
Purpose: The Age-Related Eye Disease Study 1 (AREDS1) showed that nutritional supplementation with anti-oxidants and zinc modifies the natural course of AMD. LPS induced oxidative stress diminishes the vasoconstrictor response of retinal vessels to oxygen breathing and was previously shown to be normalized by the AREDS 1 supplements. In the present study we hypothesized that the retinal vascular response can be restored by a different formulation. Methods: In this randomized, double masked, placebo-controlled parallel group study retinal red blood cell (RBC) flow and the reactivity of retinal RBC flow to 100% oxygen breathing were investigated in the absence and presence of 2ng/kg LPS in 40 healthy volunteers. They either received the supplements or placebo for 14 days. Results: Before supplementation LPS reduced retinal arterial vasoconstriction (p<0.001) and reactivity of retinal RBC flow (p=0.03) in response to hyperoxia. Supplementation did not affect baseline retinal RBC flow but normalized the LPS-induced change in the response to hyperoxia. During LPS and hyperoxia the arterial vasoconstrictor response was 4.1±1.0% after administration of placebo and 10.6±0.9% after supplementation (p = 0.005). The response of RBC flow to 100% oxygen breathing during LPS was 52.2±2.1% after administration of placebo and 59.5±2.0% after supplementation (p = 0.033). Conclusions: Our data show that the supplement used in the present study can normalize the response of retinal RBC flow to hyperoxia under LPS administration. This indicates that supplementation can prevent endothelial dysfunction induced by oxidative stress, which is assumed to play a role in the pathophysiology of AMD.
Reinhard Told; Stefan Palkovits; Doreen Schmidl; Agnes Boltz; Ghazaleh Gouya; Michael Wolzt; Katarzyna J Napora; Rene Werkmeister; Alina Popa-Cherecheanu; Gerhard Garhöfer; Leopold Schmetterer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-27
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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