Document Detail

Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections.
MedLine Citation:
PMID:  21613488     Owner:  NLM     Status:  MEDLINE    
The retina contains ganglion cells (RGCs) that respond selectively to objects moving in particular directions. Individual members of a group of ON-OFF direction-selective RGCs (ooDSGCs) detect stimuli moving in one of four directions: ventral, dorsal, nasal, or temporal. Despite this physiological diversity, little is known about subtype-specific differences in structure, molecular identity, and projections. To seek such differences, we characterized mouse transgenic lines that selectively mark ooDSGCs preferring ventral or nasal motion as well as a line that marks both ventral- and dorsal-preferring subsets. We then used the lines to identify cell surface molecules, including Cadherin 6, CollagenXXVα1, and Matrix metalloprotease 17, that are selectively expressed by distinct subsets of ooDSGCs. We also identify a neuropeptide, CART (cocaine- and amphetamine-regulated transcript), that distinguishes all ooDSGCs from other RGCs. Together, this panel of endogenous and transgenic markers distinguishes the four ooDSGC subsets. Patterns of molecular diversification occur before eye opening and are therefore experience independent. They may help to explain how the four subsets obtain distinct inputs. We also demonstrate differences among subsets in their dendritic patterns within the retina and their axonal projections to the brain. Differences in projections indicate that information about motion in different directions is sent to different destinations.
Jeremy N Kay; Irina De la Huerta; In-Jung Kim; Yifeng Zhang; Masahito Yamagata; Monica W Chu; Markus Meister; Joshua R Sanes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-08-04     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7753-62     Citation Subset:  IM    
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MeSH Terms
Axons / metabolism,  ultrastructure
Cadherins / biosynthesis
Dendrites / metabolism,  ultrastructure
Matrix Metalloproteinases, Membrane-Associated / biosynthesis
Mice, Transgenic
Motion Perception / physiology*
Photic Stimulation / methods*
Retina / cytology,  metabolism
Retinal Ganglion Cells / cytology*,  metabolism*
Visual Pathways / cytology*,  metabolism*
Grant Support
43667//Howard Hughes Medical Institute; K99 EY019355/EY/NEI NIH HHS; K99 EY019355-02/EY/NEI NIH HHS; R00 EY019355/EY/NEI NIH HHS; R00 EY019355-03/EY/NEI NIH HHS; R01 NS029169/NS/NINDS NIH HHS; R01 NS029169-22/NS/NINDS NIH HHS
Reg. No./Substance:
0/Cadherins; 0/K cadherin; EC 3.4.24.-/Matrix Metalloproteinases, Membrane-Associated; EC 3.4.24.-/Mmp17 protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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