Document Detail


Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model.
MedLine Citation:
PMID:  23196946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical management of glaucoma and optic neuropathies has traditionally focused on stages of the diseases at which there are congruent losses of visual function and optic nerve tissue. Increasing clinical and experimental evidence suggests that the electrical activity of retinal ganglion cells, as measured by pattern electroretinogram (PERG), may be altered long before measurable changes in the thickness of the retinal nerve fiber layer. In addition, PERG alterations in early glaucoma may be either reversed by lowering the intraocular pressure or induced with head-down body posture. Here we apply the well-known concept of neural plasticity to model the reversible/inducible changes of retinal ganglion cell electrical activity during a critical period of dysfunction preceding death. Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease.
Authors:
Vittorio Porciatti; Lori M Ventura
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  32     ISSN:  1536-5166     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-17     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
Affiliation:
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA. VPorciatti@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Susceptibility
Electroretinography
Humans
Models, Biological
Neuronal Plasticity / physiology*
Optic Nerve Diseases / etiology,  pathology*
Retinal Ganglion Cells / pathology*
Grant Support
ID/Acronym/Agency:
P30 EY014801/EY/NEI NIH HHS; P30-EY014801/EY/NEI NIH HHS; R01 EY014957/EY/NEI NIH HHS; R01 EY019077/EY/NEI NIH HHS; R01 EY019077/EY/NEI NIH HHS; R01EY014957/EY/NEI NIH HHS
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