Document Detail


Retinal endothelial cell apoptosis.
MedLine Citation:
PMID:  23143137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinal endothelial cell (REC) apoptosis occurs in response to a number of stressors, including high glucose, oxidative stress, hypoxia. Because these stressors are common factors in a number of ocular diseases, it is critical to understand the cellular mechanisms by which apoptosis occurs in REC. This review discusses the various models of REC used in ophthalmological research. The mechanisms responsible for REC apoptosis are discussed, as well as potential therapeutics currently under development to prevent REC apoptosis. The primary goal of this review is provide the reader with a background knowledge of the current state of research ongoing in REC apoptosis and potential avenues for future testing.
Authors:
Jena J Steinle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  17     ISSN:  1573-675X     ISO Abbreviation:  Apoptosis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-10-18     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1258-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Endothelial Cells / cytology*,  metabolism
Humans
Oxidative Stress
Retina / cytology*,  metabolism
Retinal Diseases / metabolism,  physiopathology*
Grant Support
ID/Acronym/Agency:
3P30 EY013080/EY/NEI NIH HHS; R01 EY022045/EY/NEI NIH HHS; R01EY022045/EY/NEI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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