Document Detail

Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids.
MedLine Citation:
PMID:  1386065     Owner:  NLM     Status:  MEDLINE    
Full-field electroretinograms (ERGs) were obtained from very-low-birth-weight (VLBW) neonates to determine whether omega-3 (omega-3) fatty acids are essential for normal human retinal development. Eighty-one infants born at 30.4 (standard deviation, +/- 1.5) wk gestation were, within 10 d of birth, either enrolled to receive mother's milk (naturally containing both omega-6 and omega-3 essential fatty acids) or randomized to receive one of the infant formulas. Corn oil-based Formula A contained mainly linoleic acid (18:2 omega-6) and was low in all omega-3 fatty acids. Soy oil-based Formula B contained ample alpha-linolenic acid (18:3 omega-3) but no long-chain omega-3. Formula C, supplemented with both alpha-linolenic acid and marine oils, was comparable to human milk in long-chain omega-3. Full-field ERGs were obtained in the special care nursery from infants aged 36 and 57 wk postconception. Ten healthy preterm infants born at 35 wk gestation were tested at 36 wk postconception. Significant differences were found among groups in rod ERG function. Post hoc comparisons showed that infants fed Formula A had significantly higher rod thresholds than infants receiving long-chain omega-3 (human milk, Formula C, and intrauterine). Infants receiving Formula B had intermediate thresholds that were significantly higher than those of infants receiving intrauterine nutrition. Analysis of the leading edge of the a-wave showed that b-wave differences originated at the photoreceptor level. Differences were not present in infants at 57 wk postconception. No significant differences among groups were found in cone b-waves at 36 or 57 wk postconception. Oscillatory potentials had significantly longer implicit times at 57 wk postconception in infants fed Formula A than in infants receiving human milk. These findings suggest that retinal function varies with the dietary supply of omega-3 fatty acids in VLBW infants.
D G Birch; E E Birch; D R Hoffman; R D Uauy
Related Documents :
10539755 - Double-blind, randomized trial of a synthetic triacylglycerol in formula-fed term infan...
2051555 - Osmotic load from glucose polymers.
9373845 - Postnatal inositol levels in preterm infants.
6501165 - Inductively coupled plasma emission spectroscopic determination of nine elements in inf...
18827515 - Examination of the newborn with congenital scoliosis: focus on the physical.
8302255 - Nutrient needs of the preterm infant.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  33     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-21     Completed Date:  1992-08-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2365-76     Citation Subset:  IM    
Anderson Vision Research Center, Retina Foundation of the Southwest, Dallas, Texas 75231.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast Feeding
Dark Adaptation
Dietary Fats, Unsaturated / administration & dosage*
Docosahexaenoic Acids / metabolism
Fatty Acids, Essential / blood
Fatty Acids, Omega-3 / administration & dosage*
Follow-Up Studies
Gestational Age
Infant Food
Infant, Low Birth Weight / physiology*
Infant, Newborn
Photoreceptor Cells / growth & development*,  physiology
Random Allocation
Grant Support
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reliability and validity of self and proxy reporting of morbidity data: a case study from Beirut, Le...
Next Document:  Epidermal growth factor stimulates corneal epithelial cell attachment to fibronectin through a fibro...