| Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter. | |
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MedLine Citation:
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PMID: 17765282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the condition of the retina in children with retinal degeneration due to Bardet-Biedl syndrome (BBS, n=41), Leber congenital amaurosis (LCA, n=31), or Usher syndrome (USH, n=13), the dark adapted visual threshold (DAT) and arteriolar diameters were measured. Compared to controls, the initial DATs of nearly all (83/85) were significantly elevated, and in 26/62 with serial DATs, significant progressive elevation occurred. Arteriolar diameters were significantly attenuated and narrowed with age in BBS and USH, but not LCA. Higher DATs were associated with narrower arterioles. Such non-invasive procedures can document the natural history of these retinal diseases and have the potential to assess response to future treatment. |
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Authors:
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Ronald M Hansen; Susan E Eklund; Ilan Y Benador; Julie A Mocko; James D Akula; Yao Liu; M Elena Martinez-Perez; Anne B Fulton |
Publication Detail:
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Type: Journal Article Date: 2007-08-31 |
Journal Detail:
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Title: Vision research Volume: 48 ISSN: 0042-6989 ISO Abbreviation: Vision Res. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-06 Completed Date: 2008-04-11 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: England |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aging / pathology, physiology Arterioles / pathology* Bardet-Biedl Syndrome / pathology, physiopathology Child Child, Preschool Dark Adaptation* Humans Infant Optic Atrophy, Hereditary, Leber / pathology, physiopathology Retinal Degeneration / pathology, physiopathology* Retinal Vessels / pathology* Sensory Thresholds Usher Syndromes / pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY010597-13/EY/NEI NIH HHS; S10 RR019318-01/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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