Document Detail

Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography.
MedLine Citation:
PMID:  19279309     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Morphologic changes in the retina and choroid are closely related with high myopia-related diseases. This study was conducted to evaluate the morphologic characteristics of normal highly myopic eyes. METHODS: Thirty-one phakic highly myopic eyes with no posterior abnormalities (18 patients; mean +/- SD age, 51.7 +/- 11.4 years) were enrolled. Retinal-choroidal thickness at the fovea 1.5 mm superiorly, inferiorly, nasally, and temporally and the choroidal curvature were measured in the 512 x 128 three-dimensional scan mode with spectral-domain optical coherence tomography. The degree of posterior staphyloma was determined as the sum of the vertical distance from the retinal pigment epithelial line beneath the fovea to the nasal, temporal, superior, and inferior edge of the image, including the fovea. The association of clinical data with these parameters was evaluated. RESULTS: The mean +/- SD central retinal thickness was 200.9 +/- 39.3 microm. The mean choroidal thickness at the fovea (100.5 +/- 56.9 microm) was significantly different from the temporal (125.4 +/- 59.7 microm), nasal (81.9 +/- 35.0 microm), and superior (129.4 +/- 57.5 microm) thicknesses (P < 0.01). Central retinal thickness did not correlate with age, sex, refractive error, axial length, or central choroidal thickness. Central choroidal thickness was significantly associated with refractive error (P < 0.05) and posterior staphyloma height (P < 0.01). Posterior staphyloma height was significantly correlated with refractive error and axial length (P < 0.01). Stepwise analysis indicated that choroidal thickness correlated significantly with age and posterior staphyloma height (P < 0.01). CONCLUSIONS: Posterior staphyloma formation was a key factor in choroidal thinning in highly myopic eyes. Choroidal thickness had a greater effect than retinal thickness in highly myopic eyes.
Yasushi Ikuno; Yasuo Tano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-11
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  50     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3876-80     Citation Subset:  IM    
Department of Ophthalmology, Osaka University Medical School, Osaka Japan.
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MeSH Terms
Body Weights and Measures
Choroid / pathology*
Dilatation, Pathologic
Middle Aged
Myopia, Degenerative / diagnosis*
Retina / pathology*
Scleral Diseases / diagnosis
Tomography, Optical Coherence / methods*
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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