Document Detail

Retinal blood velocity in patients with leukocyte disorders.
MedLine Citation:
PMID:  3190539     Owner:  NLM     Status:  MEDLINE    
The blue light entoptic phenomenon was used to measure retinal blood velocity in eight patients with chronic granulocytic leukemia, six patients with leukopenia, and matched control subjects. The retinal leukocyte velocity of the leukemic patients was 0.53 +/- 0.26 (mean +/- SD) mm/s, whereas that of the matched control subjects was 0.46 +/- 0.14 mm/s. There was no significant difference between these two groups (power: 96% for a difference of 0.2 mm/s and 66% for 0.1 mm/s). There was also no significant difference between the leukocyte velocities of the leukopenic patients and control subjects (0.47 +/- 0.19 mm/s and 0.55 +/- 0.14 mm/s, respectively; 89% power for a difference of 0.2 mm/s, 59% for 0.1). There was a correlation between the leukocyte count and the number of leukocytes seen in the entoptoscope. The results suggest that retinal vascular autoregulation can compensate for changes in leukocyte numbers that might have been expected to alter retinal blood flow.
T Rimmer; E M Kohner; J M Goldman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  106     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-11-29     Completed Date:  1988-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1548-52     Citation Subset:  AIM; IM    
Department of Medicine, Royal Postgraduate Medical School, London.
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MeSH Terms
Blood Flow Velocity
Cell Movement
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology*
Leukocyte Count
Leukocytes / physiopathology
Leukopenia / physiopathology*
Middle Aged
Regional Blood Flow
Retinal Vessels / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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