| Retinal blood flow in healthy young subjects. | |
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MedLine Citation:
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PMID: 22247463 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose:To characterize total retinal blood flow in a group of healthy subjects.Methods:64 healthy volunteers were included in this study. Retinal venous diameters were measured using a Dynamic Vessel Analyzer (DVA). Retinal blood velocities were measured using bi-directional laser Doppler velocimetry (LDV). All vessels with a diameter of more than 60 μm entering the optic nerve head were measured. Total retinal blood flow was measured by summing up all data from the individually measured vessels. In a subgroup of 10 healthy subjects measurements were also taken from the arterioles, and results obtained for total retinal blood flow as measured from retinal venules as well as from retinal arterioles were compared.Results:Total retinal blood flow was 44.0 ± 13.3 μl/min. Retinal blood flow was highest in the temporal inferior quadrant, followed by the temporal superior quadrant, the nasal inferior quadrant and the nasal superior quadrant (p < 0.001 each). In all quadrants retinal blood velocities were linearly correlated to vessel diameters. Retinal blood flow as measured in retinal venules (42.1 ± 13.0 μl/min) and retinal arterioles (43.3 ± 12.1 μl/min) was similar (p = 0.16).Conclusions:The present study provides reference values for total retinal blood flow in 64 healthy subjects. The inter-individual variability in retinal blood flow is high, making it unlikely that individual diagnostics can be based on measurements of retinal blood flow. Total retinal blood flow may, however, be important in risk stratification, which needs to be proven in future studies. |
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Authors:
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Gerhard Garhofer; Rene Werkmeister; Nikolaus Dragostinoff; Leopold Schmetterer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Clinical Pharmacology, Medical University of Vienna. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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