| Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy. | |
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MedLine Citation:
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PMID: 18954315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study is to determine the relationship between retinal abnormalities and brain white matter hyper-intensities (WMH) in symptomatic patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL). METHODS: Fifteen patients with CADASIL and fifteen age-matched healthy control individuals were enrolled in this study. Ophthalmological examinations were performed on all subjects and all patients with CADASIL underwent cerebral MRI scanning. Retinal artery abnormalities were graded according to the Keith-Wagener-Barker hypertensive retinopathy classification. WMH were classified as punctuate (Grade 1), nodular or early confluent (Grade 2) and diffusly confluent (Grade 3). Partial correlation was used to assess the relationship between retinal abnormalities and WMH, controlling for age. RESULTS: Retinal arteriole narrowing existed in 15 cases and 2 controls, with Grade 2 and Grade 3 being the most common grading of retinal artery narrowing in patients with CADASIL. All patients had WMH on MRI, rated as Grade 1 in one patient, Grade 2 in five patients and Grade 3 in nine patients. The correlation coefficient of retinal arteriole narrowing and WMH was 0.546 (P < 0.05). CONCLUSION: Retinal arteriole narrowing may be associated with the severity of the cerebral lesions in CADASIL. |
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Authors:
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Yang Liu; Yuan Wu; Sheng Xie; Xing-hua Luan; Yun Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: 36 ISSN: 1442-9071 ISO Abbreviation: Clin. Experiment. Ophthalmol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-02-10 Revised Date: 2009-09-23 |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: Australia |
Other Details:
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Languages: eng Pagination: 532-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Peking University First Hospital, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arterioles / abnormalities Brain / pathology* CADASIL / complications*, diagnosis* Female Humans Magnetic Resonance Imaging* Male Middle Aged Retinal Artery / abnormalities*, pathology |
| Comments/Corrections | |
Comment In:
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Clin Experiment Ophthalmol. 2009 Mar;37(2):241-2; author reply 242-3
[PMID:
19426407
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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