Document Detail


Retinal angiography: noninvasive, real-time bubble assessment from the ocular fundus.
MedLine Citation:
PMID:  19860139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formation of bubbles in tissue and vasculature from a sudden reduction in ambient pressure is likely an underlying cause of the clinical symptoms of decompression sickness (DCS). Thus, tools detecting bubbles in the vasculature may be important for evaluating DCS. Sheep were air-compressed to 6.0 ATA (30 minutes bottom time) then rapidly decompressed to the surface. A fundus camera was quickly positioned for continuous observation of the retinal vasculature. Bubbles were observed in the retinal vasculature of 25.8% (n = 31) of the sheep. Bubble onset time ranged from 5-22 minutes post-chamber and lodge time ranged from 0-70+ minutes. Bubbles were visualized mostly in the arteries of the retinal circulation. Severe vasoconstriction was captured using red-free angiography in two sheep. In two other sheep, fluorescein angiography demonstrated occluded blood flow caused by arterial gas emboli. This study demonstrates that retinal angiography is a practical tool for real-time, noninvasive detection of bubbles in the retinal circulation, a visible window to the cerebral circulation. Thus retinal angiography may prove invaluable in the early detection of arterial gas emboli in the cerebral circulation, the resolution of which is imperative to favorable neurological outcomes. This study also presents for the first time images of bubbles in the retinal circulation associated with DCS captured by a fundus camera.
Authors:
J Travis Parsons; Cameron R Smith; Jiepei Zhu; Bruce D Spiess
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc     Volume:  36     ISSN:  1066-2936     ISO Abbreviation:  Undersea Hyperb Med     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-10-28     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312954     Medline TA:  Undersea Hyperb Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-81     Citation Subset:  IM; S    
Affiliation:
Department of Anesthesiology, Virginia Commonwealth University, Richmond, Virginia, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Decompression Sickness / diagnosis*
Embolism, Air / diagnosis*,  etiology
Female
Fluorescein Angiography / instrumentation,  methods*
Fundus Oculi
Intracranial Embolism / diagnosis,  etiology
Male
Rabbits
Retinal Diseases / diagnosis*
Retinal Vessels*
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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