Document Detail


Retinal amino acid neurochemistry in health and disease.
MedLine Citation:
PMID:  23464379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Advances in basic retinal anatomy, genetics, biochemical pathways and neurochemistry have not only provided a better understanding of retinal function but have also allowed us to link basic science to retinal disease. The link with disease allowed measures to be developed that now provide an opportunity to intervene and slow down or even restore sight in previously 'untreatable' retinal diseases. One of the critical advances has been the understanding of the retinal amino acid neurotransmitters, related amino acids, their metabolites and functional receptors. This review provides an overview of amino acid localisation in the retina and examples of how retinal anatomy and amino acid neurochemistry directly links to understanding retinal disease. Also, the implications of retinal remodelling involving amino acid (glutamate) receptors are outlined in this review and insights are presented on how understanding of detrimental and beneficial retinal remodelling will provide better outcomes for patients using strategies for the preservation or restoration of vision. An internet-based database of retinal images of amino acid labelling patterns and other amino acid-related images in health and disease is located at http://www.aminoacidimmunoreactivity.com.
Authors:
Michael Kalloniatis; Chee Seang Loh; Monica L Acosta; Guido Tomisich; Yuan Zhu; Lisa Nivison-Smith; Erica L Fletcher; Jacqueline Chua; Daniel Sun; Niru Arunthavasothy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-7
Journal Detail:
Title:  Clinical & experimental optometry : journal of the Australian Optometrical Association     Volume:  -     ISSN:  1444-0938     ISO Abbreviation:  Clin Exp Optom     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703442     Medline TA:  Clin Exp Optom     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-18     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Clinical and Experimental Optometry © 2013 Optometrists Association Australia.
Affiliation:
Centre for Eye Health, University of New South Wales, Sydney, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia; Department of Optometry and Vision Sciences, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand. m.kalloniatis@unsw.edu.au.
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