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Retinal Vascular Fractal Dimension and Its Relationship With Cardiovascular and Ocular Risk Factors.
MedLine Citation:
PMID:  22840482     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To examine the influence of a range of cardiovascular risk factors and ocular conditions on retinal vascular fractal dimension in the Singapore Malay Eye Study. DESIGN: Population-based cross-sectional study. METHODS: Fractal analysis of the retinal vessels is a method to quantify the global geometric complexity of the retinal vasculature. Retinal vascular fractal dimension (D(f)) and caliber were measured from retinal photographs using a computer-assisted program. D(f)and arteriolar caliber were combined to form a retinal vascular optimality score (ranging from 0 to 3). Data on cardiovascular and ocular factors were collected from all participants based on a standardized protocol. RESULTS: Two thousand nine hundred thirteen (88.8% of 3280 participants) persons had retinal photographs of sufficient quality for the measurement. The mean D(f) was 1.405 (standard deviation, 0.046; interquartile range, 1.243 to 1.542). In the multiple linear regression analysis, after controlling for gender, serum glucose, intraocular pressure, anterior chamber depth, and retinal vascular caliber, smaller D(f) was associated independently with older age (standardized regression coefficient [sβ] = -0.311; P < .001), higher mean arterial blood pressure (sβ = -0.085; P < .001), a more myopic spherical equivalent (sβ = 0.152; P < .001), and presence of cataract (sβ = -0.107; P < .001). Retinal vascular optimality score was associated significantly with higher mean arterial blood pressure (P > .001 for trend). CONCLUSIONS: Age, blood pressure, refractive error, and lens opacity had significant influence on retinal vascular fractal measurements. A new score of retinal vascular optimality combining fractals and caliber showed strong association with blood pressure. Quantitative analysis of retinal vasculature therefore may provide additional information on microvascular architecture and optimality.
Authors:
Carol Y Cheung; George N Thomas; Wanting Tay; M Kamran Ikram; Wynne Hsu; Mong L I Lee; Qiangfeng Peter Lau; Tien Yin Wong
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-26
Journal Detail:
Title:  American journal of ophthalmology     Volume:  -     ISSN:  1879-1891     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore,; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore,; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
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