| Retinal Pigment Epithelium Tears in Age-Related Macular Degeneration Treated with Antiangiogenic Drugs: A Controlled Study with Long Follow-Up. | |
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MedLine Citation:
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PMID: 22710369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To study whether anti-vascular endothelial growth factor (VEGF) therapy improves visual acuity (VA) in patients with exudative age-related macular degeneration (AMD) complicated with retinal pigment epithelium (RPE) tears. Methods: Retrospective case-control series. Group I (control group) included 9 patients with RPE tears that received no treatment, and group II (intervention group) incorporated 12 patients treated with anti-VEGF. Results: A statistically significant difference was found in VA between the groups from the 3rd month to the final follow-up (p = 0.034). Final VA improved in the treatment group (p = 0.015). No differences were found in central macular thickness between the groups either before or after treatment. Mean number of injections in group II was 5.75 (SD = 1.19). Most patients presented a grade 3 rip. All lesions were inactive at the end of follow-up in group II and 1 remained active in group I. The number of final atrophic/disciform scars was 6/8 in group I and 7/5 in group II. Conclusions: RPE tears treated with antiangiogenic drugs experienced functional benefit. To the authors' knowledge, this is the first controlled series reporting effectiveness of suppression of neovascular activity with antiangiogenic treatment after RPE rip in AMD. |
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Authors:
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Rosa M Coco; M Rosa Sanabria; Arturo G Hernandez; Marta Fernández Muñoz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-15 |
Journal Detail:
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Title: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde Volume: - ISSN: 1423-0267 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0054655 Medline TA: Ophthalmologica Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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