| Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review. | |
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MedLine Citation:
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PMID: 23406680 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD. |
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Authors:
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Brad P Barnett; James T Handa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-08 |
Journal Detail:
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Title: Gerontology Volume: - ISSN: 1423-0003 ISO Abbreviation: Gerontology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7601655 Medline TA: Gerontology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 S. Karger AG, Basel. |
Affiliation:
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Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Md., USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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