Document Detail


Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review.
MedLine Citation:
PMID:  23406680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated.
OBJECTIVE: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD.
METHODS: A literature review.
RESULTS: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis.
CONCLUSIONS: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.
Authors:
Brad P Barnett; James T Handa
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-08
Journal Detail:
Title:  Gerontology     Volume:  59     ISSN:  1423-0003     ISO Abbreviation:  Gerontology     Publication Date:  2013  
Date Detail:
Created Date:  2013-06-26     Completed Date:  2014-02-10     Revised Date:  2014-02-13    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / immunology,  metabolism*,  pathology
Animals
DNA Damage
DNA, Mitochondrial / genetics,  metabolism
Humans
Immunity, Innate
Macular Degeneration / etiology*,  metabolism*,  pathology
Mice
Oxidative Stress
Polymorphism, Genetic
Retina / immunology,  metabolism*,  pathology
Retinal Pigment Epithelium / metabolism
Risk Factors
Smoking / adverse effects
Grant Support
ID/Acronym/Agency:
EY019904/EY/NEI NIH HHS; EY14005/EY/NEI NIH HHS; P30EY001765/EY/NEI NIH HHS; R01 EY014005/EY/NEI NIH HHS; R01 EY019904/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epigenetic inactivation of the MIR129-2 in hematological malignancies.
Next Document:  Ferromagnetism in ZnO:Co originating from a hydrogenated Co-O-Co complex.