| Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. | |
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MedLine Citation:
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PMID: 19805174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood vessel formation during ischemia and wound healing requires coordination of the inflammatory response with genes that regulate blood vessel assembly. Here we show that the reticulon family member 4B, aka Nogo-B, is upregulated in response to ischemia and is necessary for blood flow recovery secondary to ischemia and wound healing. Mice lacking Nogo-B exhibit reduced arteriogenesis and angiogenesis that are linked to a decrease in macrophage infiltration and inflammatory gene expression in vivo. Bone marrow-derived macrophages isolated from Nogo knock-out mice have reduced spreading and chemotaxis due to impaired Rac activation. Bone marrow reconstitution experiments show that Nogo in myeloid cells is necessary to promote macrophage homing and functional recovery after limb ischemia. Thus, endogenous Nogo coordinates macrophage-mediated inflammation with arteriogenesis, wound healing, and blood flow control. |
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Authors:
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Jun Yu; Carlos Fernández-Hernando; Yajaira Suarez; Michael Schleicher; Zhengrong Hao; Paulette L Wright; Annarita DiLorenzo; Themis R Kyriakides; William C Sessa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-09-25 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-11-03 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 17511-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Amistad Research Building, Yale University School of Medicine, New Haven, CT 06519, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology Cell Movement / physiology Inflammation / prevention & control Ischemia / physiopathology, prevention & control Macrophages / drug effects, physiology* Mice Mice, Inbred C57BL Mice, Knockout Monocytes / drug effects, physiology Myelin Proteins / deficiency, genetics, pharmacology*, physiology* Regional Blood Flow / physiology Up-Regulation Wound Healing / physiology |
| Grant Support | |
ID/Acronym/Agency:
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N01-HV-28186/HV/NHLBI NIH HHS; P01 HL 70295/HL/NHLBI NIH HHS; R01 HL 061371/HL/NHLBI NIH HHS; R01 HL 064793/HL/NHLBI NIH HHS; R01 HL 081190/HL/NHLBI NIH HHS; R01 HL081190-07/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myelin Proteins; 0/Nogo protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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