Document Detail

Reticuloendothelial system function and humoral factor deficiency following acute hemorrhage.
MedLine Citation:
PMID:  76503     Owner:  NLM     Status:  MEDLINE    
The present study has shown that following acute hemorrhage (equivalent to 3% body weight withdrawn over 20 min) in the rat, there is a large reduction (56% of control) in circulating alpha-2-glycoprotein opsonic activity. The reduction in this plasma opsonic activity was near maximal by the completion of blood withdrawal and was maintained throughout a 2-h hypotension period. There was no trend toward recovery of the opsonic activity when evaluated 15 min following reinfusion of shed blood in animals that were hypotensive for 0, 30, and 120 min. Reticuloendothelial system (RES) phagocytic function, as assessed from the carbon clearance rate (phagocytic index) following reinfusion of the shed blood, was depressed in animals that were hypotensive for 0, 30, and 120 min. Thus, phagocytic index followed a time course similar to the depression of opsonic activity. The observed close temporal relationship between alpha-2-glycoprotein opsonic deficiency and depression of RES clearance further supports the possible role of a humoral opsonic deficiency in mediating the RES phagocytic depression during circulatory shock.
F K Carr; D J Loegering
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  56     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-28     Completed Date:  1978-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Hemorrhage / blood,  physiopathology*
Mononuclear Phagocyte System / physiopathology*
Opsonin Proteins / analysis*
Time Factors
alpha-Macroglobulins / metabolism*
Reg. No./Substance:
0/Opsonin Proteins; 0/alpha-Macroglobulins

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