Document Detail


Reticuloendothelial system blockade promotes progression from mild to severe acute pancreatitis in the opossum.
MedLine Citation:
PMID:  11303135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relation between hepatic reticuloendothelial system (RES) dysfunction and the development of acute biliary pancreatitis. In an opossum model, the authors tested the hypothesis that RES blockade can turn the mild pancreatitis seen after pancreatic duct obstruction (PDO) into the severe form. SUMMARY BACKGROUND DATA: Biliary obstruction is considered the decisive event in gallstone pancreatitis. Suppression of the RES occurs during biliary obstruction. METHODS: Eighteen opossums were placed into three groups of six animals each: group A, RES blockade with lambda-carrageenan; group B, PDO; and group C, PDO and RES blockade with carrageenan. The severity of pancreatitis was evaluated by enzyme serum levels and percentage of pancreatic tissue necrosis. RES capacity was measured by dynamic liver scintigraphy, and hepatic blood flow was documented using the hydrogen clearance technique. RESULTS: No changes in hepatic blood flow occurred in groups A to C. RES capacity was suppressed in groups A and C; in group B, RES function remained unchanged. In group A, amylase and lipase levels remained normal, 3 +/- 1.9% of pancreatic tissue were necrotic. The animals in group B developed mild edematous pancreatitis with an increase in amylase and lipase levels and 15 +/- 10% of pancreatic necrosis. In group C, amylase and lipase increased significantly and histology revealed severe necrotizing pancreatitis, with 72 +/- 11% of necrotic areas. CONCLUSIONS: Artificial RES blockade can promote the progression from mild pancreatitis as observed after PDO to the severe necrotizing form of the disease. Thus, RES dysfunction resulting from biliary obstruction might be an important cofactor in the pathogenesis of bile-induced pancreatitis.
Authors:
C Schleicher; J C Baas; H Elser; N Senninger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  233     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-05-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-36     Citation Subset:  AIM; IM    
Affiliation:
Department of General Surgery, University of Muenster, Muenster, Germany. cschlei@medsnt01.uni-muenster.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amylases / blood
Animals
Carrageenan
Cholelithiasis / complications
Cholestasis / complications*
Female
Lipase / blood
Mononuclear Phagocyte System / physiology*
Opossums*
Pancreas / pathology*
Pancreatic Ducts / surgery
Pancreatitis / etiology*,  pathology
Pancreatitis, Acute Necrotizing / etiology*,  pathology
Chemical
Reg. No./Substance:
9000-07-1/Carrageenan; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases
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