Document Detail

Reticulated acanthoma with sebaceous differentiation.
MedLine Citation:
PMID:  16625081     Owner:  NLM     Status:  MEDLINE    
Reticulated acanthoma with sebaceous differentiation (RASD) is characterized by the reticulated proliferation of spinous cells with aggregates of mature sebocytes in the bases of the strands of the keratinocytes, often linking rete ridges. Here, we report the first case reported as RASD. A 55-year-old woman presented with a 15-year history of a slightly pruritic patch on the upper back, and the histology was typical for RASD. She had been bothered by a yellow discharge from the tumor. Skin tumors with sebaceous differentiation are occasionally associated with Muir-Torre syndrome. However, immunohistochemical staining for mutS homolog 2 (MSH-2) and mutL homolog 1 (MLH-1) showed positive staining within the nuclei of sebaceous cells and cells in the dermis. Therefore, it is most likely that the present case is not associated with Muir-Torre syndrome.
Kazuyoshi Fukai; Junko Sowa; Masamitsu Ishii
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  28     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-20     Completed Date:  2006-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-61     Citation Subset:  IM    
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Adaptor Proteins, Signal Transducing
Carrier Proteins / analysis
Cell Proliferation
Epithelium / pathology
Keratinocytes / pathology
Middle Aged
Mucin-1 / analysis
MutS Homolog 2 Protein / analysis
Neoplasms, Glandular and Epithelial / pathology*
Nuclear Proteins / analysis
Parakeratosis / pathology
Sebaceous Glands / pathology*
Skin Neoplasms / pathology*
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/MLH1 protein, human; 0/Mucin-1; 0/Nuclear Proteins; EC Homolog 2 Protein

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