Document Detail

Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues.
MedLine Citation:
PMID:  16133356     Owner:  NLM     Status:  MEDLINE    
Perineurioma represents a recently described and relatively rare neoplasm in the spectrum of benign peripheral nerve sheath tumours composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen (EMA). In addition to intraneural, extraneural and sclerosing perineurioma, rare variants of perineurioma may occur, and their knowledge is important in the differential diagnosis of mesenchymal tumours of different lines of differentiation and clinically more aggressive neoplasms. We present a case of deep-seated reticular perineurioma arising on the upper arm of a 34-year-old female and a case of a dermal plexiform perineurioma arising on the lower lip of a 60-year-old female. The diagnosis was confirmed in both cases immunohistochemically; neoplastic cells stained positively for EMA and for the newly described perineurial markers, claudin-1 and glut-1. The morphological spectrum and the differential diagnosis of perineurial neoplasms of skin and soft tissues are discussed.
Thomas Mentzel; Heinz Kutzner
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-10-19
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  447     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-01-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  677-82     Citation Subset:  IM    
Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6/1, 88048, Friedrichshafen, Germany.
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MeSH Terms
Diagnosis, Differential
Fibroma / pathology
Glucose Transporter Type 1 / metabolism
Lipoma / pathology
Membrane Proteins / metabolism
Middle Aged
Mucin-1 / metabolism
Nerve Sheath Neoplasms / metabolism,  pathology*
S100 Proteins / metabolism
Sarcoma / pathology
Skin Neoplasms / metabolism,  pathology*
Soft Tissue Neoplasms / metabolism,  pathology*
Reg. No./Substance:
0/Glucose Transporter Type 1; 0/Membrane Proteins; 0/Mucin-1; 0/S100 Proteins; 0/claudin 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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