Document Detail

Retention behaviour of some barbituric acid derivatives on a polyethylene-coated silica column.
MedLine Citation:
PMID:  7952034     Owner:  NLM     Status:  MEDLINE    
The retention of 45 barbituric acid derivatives was determined on a polyethylene-coated silica column (PEE) in unbuffered methanol-water eluent mixtures. Each derivative showed a symmetric peak shape in each eluent and the capacity factor decreased monotonously with increasing concentration of methanol in the eluent. Stepwise regression analysis indicated that the retention of barbituric acid derivatives is mainly governed by the molecular lipopholicity and, to a lesser extent, by steric effects of the various substituents. This finding indicates that the polyethylene-coated silica behaves as a real reversed-phase chromatographic support with slightly different retention characteristics.
E Forgács; T Cserháti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of chromatography. B, Biomedical applications     Volume:  656     ISSN:  1572-6495     ISO Abbreviation:  J. Chromatogr. B, Biomed. Appl.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-30     Completed Date:  1994-11-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421796     Medline TA:  J Chromatogr B Biomed Appl     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
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MeSH Terms
Barbiturates / chemistry,  isolation & purification*
Chemistry, Physical
Chromatography, High Pressure Liquid
Multivariate Analysis
Physicochemical Phenomena
Silicon Dioxide
Reg. No./Substance:
0/Barbiturates; 0/Polyethylenes; 7631-86-9/Silicon Dioxide

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