Document Detail


Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis.
MedLine Citation:
PMID:  22176921     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIMS: In this review, we discuss the mechanisms behind the binding of low-density lipoproteins (LDL) to the arterial wall and how this interaction might be targeted to prevent atherosclerosis.
DATA SYNTHESIS: An increasing body of evidence shows that accumulation of LDL in the vessel wall is a critical step in the development of atherosclerosis. The retained lipoproteins subsequently provoke an inflammatory response that ultimately leads to atherosclerosis. In the arterial wall, LDL binds ionically to proteoglycans in the extracellular matrix. In particular, proteoglycans with elongated glycosaminoglycan (GAG) chains seem to play a crucial role in this process.
CONCLUSIONS: The LDL-proteoglycan interaction is a highly regulated process that might provide new therapeutic targets against cardiovascular disease.
Authors:
P Fogelstrand; J Borén
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  22     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden.
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