Document Detail

Retention of African American women in cancer genetics research.
MedLine Citation:
PMID:  18076114     Owner:  NLM     Status:  MEDLINE    
Although retention is a critical component of longitudinal cancer genetics research, limited empirical data are available on predictors of study retention among populations that are difficult to enroll. We evaluated predictors of retention in cancer genetics research among African American women at increased risk for having a BRCA1 and BRCA2 (BRCA1/2) mutation. Participants were African American women (n = 192) at increased risk for hereditary breast-ovarian cancer who were enrolled in a longitudinal genetic counseling research study. Retention was evaluated separately for the 1- and 6-month follow-ups and in terms of overall retention (e.g., completion of both telephone interviews). Seventy-three percent of women and 65% of women were retained at the 1- and 6-month follow-ups respectively; in terms of overall retention, 60% of women were retained in both follow-up telephone interviews. Predictors of retention at 1-month included being employed (OR = 2.47, 95% CI = 1.24, 4.93, P = 0.01) whereas predictors of overall retention included having a personal history of breast and/or ovarian cancer (OR = 2.06, 95% CI = 1.07, 3.95, P = 0.03) and having completed genetic counseling (OR = 2.63, 95% CI = 1.39, 4.98, P = 0.003). These data suggest that once enrolled in genetic counseling research, the majority of African American women will continue to participate, especially if concrete clinical services are provided.
Chanita Hughes Halbert; Deja Love; Tynisha Mayes; Aliya Collier; Benita Weathers; Lisa Kessler; Jill Stopfer; Deborah Bowen; Susan Domchek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  146A     ISSN:  1552-4833     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-26     Completed Date:  2008-02-25     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-73     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Psychiatry, Abramson Cancer Center, and the Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
African Americans / genetics*,  psychology*
Attitude to Health
Breast Neoplasms / epidemiology,  genetics,  psychology*
Genes, BRCA1
Genes, BRCA2
Genetic Counseling*
Genetic Predisposition to Disease
Logistic Models
Middle Aged
Ovarian Neoplasms / genetics,  psychology*
Retention (Psychology)
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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