Document Detail

Rete mirabile of goat: in vitro effects of adrenergic stimulation.
MedLine Citation:
PMID:  6661647     Owner:  NLM     Status:  MEDLINE    
The carotid rete of the goat, a network of small arteries, is placed in the pathway of the main arteries which supply the brain. This structure lies within the cavernous sinus on each side of the pituitary. The presence of a carotid rete in many mammals has led to frequent speculations about its physiological function. The present study was designed to examine comparatively the responsiveness of goat retial and cerebral arteries to direct or indirect adrenergic stimulation. The contractile response of isolated retial arteries (150-500 micron in external diameter) to norepinephrine (10(-8) - 10(-4)M), field electrical stimulation (2-16 c/s), and tyramine (10(-6) - 10(-3) M) was negligible. In contrast, cerebral arteries of 300-500 micron in external diameter exhibited dose- or frequency-dependent contractions qualitatively similar to those previously described in larger cerebral arteries. The norepinephrine content in the walls of retial arteries was about 13% of that measured in cerebral arteries. These results suggest that the role of the carotid rete in the regulation of resistance to blood flow during adrenergic stimulation is negligible or nonexistent.
G Diéguez; M V Conde; B Gómez; J R Iglesias; J Marín; S Lluch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  289     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-4     Citation Subset:  IM    
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MeSH Terms
Adrenergic Fibers / drug effects*
Carotid Arteries / innervation*
Cerebral Arteries / innervation
Cerebrovascular Circulation / drug effects*
Electric Stimulation
Muscle, Smooth, Vascular / innervation
Norepinephrine / pharmacology*
Tyramine / pharmacology*
Vasoconstriction / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 51-67-2/Tyramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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