Document Detail

Retarding effect of lowered heart rate on coronary atherosclerosis.
MedLine Citation:
PMID:  6484569     Owner:  NLM     Status:  MEDLINE    
The role of heart rate in the development of coronary atherosclerosis was assessed in adult male cynomolgus monkeys (Macaca fascicularis). Heart rate was lowered in six animals by surgical ablation of the sinoatrial node. A sham procedure, which included all of the surgical steps except for sinoatrial node ablation, was carried out in eight animals. All of the monkeys were fed an atherogenic high cholesterol diet for 6 months, and heart rates were monitored repeatedly by telemetry during 24-hour test periods. Coronary atherosclerosis in animals with postoperative heart rates less than the preoperative mean for all of the animals that underwent surgery was less than half that of animals with heart rates above the mean or of diet-fed control animals not subjected to surgery. Groups did not differ in blood pressure, serum lipids, or body weight. These results suggest that heart rate in itself may contribute to the mechanisms by which behavioral patterns and physical training influence coronary artery disease.
P A Beere; S Glagov; C K Zarins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  226     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-02     Completed Date:  1984-11-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-2     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis / etiology*
Blood Pressure
Body Weight
Cholesterol / blood
Coronary Vessels*
Diet, Atherogenic
Heart Rate*
Macaca fascicularis
Myocardial Contraction
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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