| Retailoring docosahexaenoic acid-containing phospholipid species during impaired neurogenesis following omega-3 alpha-linolenic acid deprivation. | |
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MedLine Citation:
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PMID: 20557429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diminished levels of docosahexaenoic acid (22:6n-3), the major fatty acid (FA) synthesized from alpha-linolenic acid (18:3n-3), have been implicated in functional impairment in the developing and adult brain. We have now examined the changes in phospholipid (PL) molecular species in the developing postnatal cortex, a region recently shown to be affected by a robust aberration in neuronal cell migration, after maternal diet alpha-linolenic acid deprivation (Yavin et al. (2009)Neuroscience162(4),1011). The frontal cortex PL composition of 1- to 4-week-old rats was analyzed by gas chromatography and electrospray ionization/tandem mass spectrometry. Changes in the cortical PL molecular species profile by dietary means appear very specific as 22:6n-3 was exclusively substituted by docosapentaenoic acid (22:5n-6). However, molecular species were conserved with respect to the combination of specific polar head groups (i.e. ethanolamine and serine) in sn-3 and defined saturated/mono-unsaturated FA in sn-1 position even when the sn-2 FA moiety underwent diet-induced changes. Our results suggest that substitution of docosahexaenoic acid by docosapentaenoic acid is tightly regulated presumably to maintain a proper biophysical characteristic of membrane PL molecular species. The importance of this conservation may underscore the possible biochemical consequences of this substitution in regulating certain functions in the developing brain. |
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Authors:
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Annette Brand; Michael A Crawford; Ephraim Yavin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-16 |
Journal Detail:
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Title: Journal of neurochemistry Volume: 114 ISSN: 1471-4159 ISO Abbreviation: J. Neurochem. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: England |
Other Details:
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Languages: eng Pagination: 1393-404 Citation Subset: IM |
Affiliation:
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Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cerebral Cortex / chemistry, drug effects, growth & development*, metabolism* Docosahexaenoic Acids / chemistry, metabolism* Female Humans Neurogenesis / drug effects, physiology* Phospholipids / chemistry, metabolism* Pregnancy Rats Rats, Wistar alpha-Linolenic Acid / administration & dosage, chemistry, deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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