Document Detail

Resynchronization: considering device-based cardiac therapy in older adults.
MedLine Citation:
PMID:  23581915     Owner:  NLM     Status:  MEDLINE    
Cardiac resynchronization therapy (CRT) is a device-based treatment available to select individuals with systolic heart failure (HF), a large proportion of whom are aged 65 and older. As the field of CRT advances, together with shifting demographics and expanded indications for implantation, there is a need for practitioners caring for older adults to understand what is and is not known about the use of CRT specifically in this population. Clinical trials demonstrating benefits for severe and mild HF have uncertain generalizability to older adults. Other studies demonstrate that device-related complications may be more common with CRT than with simpler devices and more common in older adults. CRT clinical trials also may not adequately capture outcomes and concerns specific to older adults, including quality of life and end-of-life care experiences. Informed decision-making by clinicians, policy-makers, and patients will require greater understanding of the use and outcomes of CRT in older persons.
Daniel B Kramer; Matthew R Reynolds; Susan L Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-03-21
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  61     ISSN:  1532-5415     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-06-17     Revised Date:  2014-11-12    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
Copyright Information:
© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.
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MeSH Terms
Age Factors
Aged, 80 and over
Cardiac Resynchronization Therapy / methods*,  statistics & numerical data
Comparative Effectiveness Research*
Disease Management
Health Services for the Aged / organization & administration
Heart Failure / therapy*
Middle Aged
Outcome and Process Assessment (Health Care)
Quality of Life*
Severity of Illness Index*
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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