| Resveratrol regulates the expression of LXR-alpha in human macrophages. | |
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MedLine Citation:
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PMID: 16901463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The naturally occurring polyphenol resveratrol has been associated with the beneficial effects of red wine consumption on cardiovascular disease and shown to inhibit atherosclerosis in animal models. To determine if resveratrol affects the expression of genes that control lipid homeostasis in human macrophages, we measured expression changes in the LXR-alpha pathway, crucial to cholesterol efflux, and in genes that mediate lipoprotein uptake. Resveratrol treatment of THP-1 macrophages induced LXR-alpha at mRNA and protein levels. Increased recruitment of RNA polymerase II to the LXR-alpha promoter suggested that up-regulation was at least partly mediated by transcriptional mechanisms. Resveratrol also induced LXR-alpha in human monocyte-derived macrophages together with elevated ABCA1 and ABCG1 mRNA levels. Moreover, resveratrol repressed the expression of the lipid uptake genes LPL and SR-AII. The ability of resveratrol to modulate expression of the genes involved in lipid uptake and efflux suggests that polyphenols can potentially limit cholesterol accumulation in human macrophages. |
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Authors:
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Marie Sevov; Lioudmila Elfineh; Lucia B Cavelier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-01 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 348 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-22 Completed Date: 2006-10-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1047-54 Citation Subset: IM |
Affiliation:
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Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line, Tumor DNA-Binding Proteins / biosynthesis*, genetics* Gene Expression Regulation / drug effects Humans Lipid Metabolism / drug effects, genetics* Macrophages / drug effects*, metabolism* Orphan Nuclear Receptors RNA, Messenger / biosynthesis Receptors, Cytoplasmic and Nuclear / biosynthesis*, genetics* Stilbenes / pharmacology* Up-Regulation / drug effects, genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Orphan Nuclear Receptors; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Stilbenes; 0/liver X receptor; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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