Document Detail

Resveratrol and quercetin inhibit angiogenesis in vitro.
MedLine Citation:
PMID:  11485823     Owner:  NLM     Status:  MEDLINE    
Resveratrol and quercetin are polyphenolic compounds found in grapes, red wine and other food products. In this study, we examined the effect of resveratrol and quercetin on the inhibition of angiogenesis in vitro. Resveratrol and quercetin inhibited the growth of bovine aorta endothelial (BAE) cells in a concentration-dependent manner (6-100 microM).The migration of BAE was obviously inhibited by resveratrol and weakly inhibited by quercetin. When the lengths of all tubes constructed in the 3-D culture system with or without resveratrol or quercetin were measured, resveratrol was found to inhibit the tube formation of BAE cells in a concentration-dependent manner (6-100 microM). On the other hand, quercetin at concentrations above 100 microM significantly inhibited the tube formation of vascular endothelial cells. From these results, we suggest that resveratrol and quercetin may prove useful in the development of useful therapeutic agents or preventive food factors for tumor angiogenesis.
K Igura; T Ohta; Y Kuroda; K Kaji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  171     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2001-09-20     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Laboratory of Cell and Molecular Biology of Aging, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, 422-8526, Shizuoka, Japan.
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MeSH Terms
Angiogenesis Inhibitors / pharmacology*
Aorta / cytology
Cell Division / drug effects
Cell Movement / drug effects
Cells, Cultured / drug effects
Endothelium, Vascular / cytology,  drug effects*
Neovascularization, Physiologic / drug effects*
Quercetin / pharmacology*
Stilbenes / pharmacology*
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Stilbenes; 117-39-5/Quercetin; Q369O8926L/resveratrol

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