Document Detail


Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cells.
MedLine Citation:
PMID:  20307562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol (3,4',5-trihydroxystilbene), a natural polyphenol found in red grapes, berries and peanuts, exhibits anti-inflammatory, cell-growth modulatory, and anticarcinogenic effects. In this report, we show that resveratrol inhibited cholera toxin (CT)-induced cyclic AMP accumulation in Vero cells. Resveratrol suppressed the CT activity by suppressing the internalization of CT and traffic to the Golgi apparatus without affecting CT binding to cells. Further, resveratrol partially precipitated CT from solution, and suppressed CT ADP-ribosyltransferase activity. These data suggest that resveratrol may inhibit CT-induced activity directly by associating with CT and suppressing its enzymatic activity, and indirectly by inhibiting CT endocytosis into cells.
Authors:
Naoko Morinaga; Kinnosuke Yahiro; Masatoshi Noda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-20
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  56     ISSN:  1879-3150     ISO Abbreviation:  Toxicon     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-02     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. nmorinaga@faculty.chiba-u.jp
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MeSH Terms
Descriptor/Qualifier:
ADP Ribose Transferases / antagonists & inhibitors
Animals
Cercopithecus aethiops
Cholera Toxin / antagonists & inhibitors*,  metabolism
Cyclic AMP / metabolism*
Endocytosis / drug effects
Enzyme Inhibitors / pharmacology*
Flavonoids / pharmacology*
Membrane Microdomains / metabolism
Osmolar Concentration
Phenols / pharmacology*
Polyphenols
Stilbenes / pharmacology*
Time Factors
Vero Cells
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Flavonoids; 0/Phenols; 0/Polyphenols; 0/Stilbenes; 60-92-4/Cyclic AMP; 9012-63-9/Cholera Toxin; EC 2.4.2.-/ADP Ribose Transferases; Q369O8926L/resveratrol

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