| Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. | |
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MedLine Citation:
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PMID: 21953348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Alcohol intake is inversely related to rheumatoid arthritis (RA) disease incidence and severity. Resveratrol, a safe, well-described plant-derived compound, possesses anti-inflammation and immune-regulatory properties and is present in red wine. As such, it could mediate anti-inflammatory properties of the latter and offer novel therapeutic utility in is own right. OBJECTIVE: To evaluate the therapeutic effect of resveratrol on collagen-induced arthritis (CIA) and its putative immune modulation in mice. METHODS: CIA was induced in DBA1 mice by immunisation with collagen II. Different doses of resveratrol were administered before or after the development of CIA. The levels of antibody and cytokines in serum or in draining lymph node (DLN) lymphocyte culture supernatants were measured by ELISA and Th17 cell development in DLN was monitored by flow cytometry. RESULTS: Either prophylactic or therapeutic administration of resveratrol attenuated clinical parameters and bone erosion in CIA mice. The arthritis-protective effects were associated with markedly reduced serum levels of pro-inflammatory cytokines and collagen-specific, but not total, IgG, and with reduced numbers of Th17 cells and the production of IL-17 in DLN. CONCLUSION: Resveratrol modulates inflammatory arthritis in rodents by selectively suppressing key cellular and humoral responses necessary for disease development. This may partly explain the protective effects of red wine but importantly may offer a novel, effective and safe pathway whereby novel agents could be developed to treat RA. |
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Authors:
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Gao Xuzhu; Mousa Komai-Koma; Bernard P Leung; Hwee Siew Howe; Charles McSharry; Iain B McInnes; Damo Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-09-27 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 71 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-02 Completed Date: 2012-02-08 Revised Date: 2013-06-03 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 129-35 Citation Subset: IM |
Affiliation:
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Institute of Infection, Immunity and Infl ammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology, therapeutic use Arthritis, Experimental / drug therapy*, immunology, prevention & control Autoantibodies / biosynthesis B-Lymphocytes / drug effects*, immunology Cells, Cultured Cytokines / biosynthesis Dose-Response Relationship, Drug Drug Evaluation, Preclinical / methods Immunosuppressive Agents / administration & dosage, pharmacology, therapeutic use* Inflammation Mediators / metabolism Male Mice Mice, Inbred DBA Stilbenes / administration & dosage, pharmacology, therapeutic use* Th17 Cells / drug effects*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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//Arthritis Research UK; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Autoantibodies; 0/Cytokines; 0/Immunosuppressive Agents; 0/Inflammation Mediators; 0/Stilbenes; Q369O8926L/resveratrol |
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