| Resveratrol modifies tephritid fruit fly response to radiation but not nutritional stress. | |
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MedLine Citation:
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PMID: 22145646 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Purpose: Resveratrol (3, 5, 4'-trihydroxystilbene) is a polyphenol compound found in many plants and fruits that has antioxidant and radioprotective properties. Two model invertebrates, B. dorsalis (oriental fruit fly) and B. cucurbitae (melon fly) (Diptera: Tephritidae), were studied to determine if the addition of resveratrol to an artificial diet could modify their response to radiation and nutritional stress. Materials and Methods: Resveratrol at concentrations of 0, 50, 100, or 200 μM of was incorporated into a liquid larval fruit fly diet. Third instars were treated with 1) a radiation dose of 30 Gy (radiation stress), 2) a wheat germ oil-deficient diet (nutritional stress), or 3) left untreated as a control. Results: The addition of resveratrol to the diet partially mitigated the adverse effects of radiation on several life history parameters. In B. cucurbitae, a significantly higher 49-53% of adults could fly when 50-200 μM resveratrol was added to the diet compared with 32% in irradiated flies reared without resveratrol. B. cucurbitae egg hatch in irradiated insects improved significantly from 46 to 66% with the addition of 50 μM resveratrol. In irradiated B. dorsalis, adult emergence was significantly improved from 12 to 29% with the addition of 100 μM resveratrol. Resveratrol did not mediate any of the negative effects of a wheat germ oil-deficient diet in either species. Conclusion: Resveratrol has potential as a means to partially mitigate the adverse effects of radiation treatment under the conditions tested. This study is the first to show that resveratrol can have radioprotective effects in invertebrates. |
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Authors:
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Chiou Ling Chang; Peter Follett |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
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Title: International journal of radiation biology Volume: - ISSN: 1362-3095 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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