| Resveratrol inhibits reproductive toxicity induced by deoxynivalenol. | |
| | |
MedLine Citation:
|
PMID: 22540658 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The aim of this in vitro study was to examine the release of progesterone by porcine ovarian granulosa cells (GCs) after exposure to toxic concentrations of deoxynivalenol (DON), resveratrol (RSV), and their combination (DON with RSV). Ovarian granulosa cells were incubated without (control) or with treatments of natural substances at various doses for 24 h: RSV (10, 30 and 50 μg/mL) / DON (2000, 3000 and 5000 ng/mL), and their combination (10 μg/mL of RSV with 2000 ng/mL of DON; 30 μg/mL of RSV with 3000 ng/mL of DON; 50 μg/mL of RSV with 5000 ng/mL of DON). Progesterone was determined by radioimmunoassay (RIA). Progesterone release was significantly (P < 0.05) stimulated by RSV at the doses 50 μg/mL but not at 30 and 10 μg/mL and by DON treatment at all used doses (2000, 3000 and 5000 ng/mL). RSV in combination with DON stimulated significantly (P < 0.05) the progesterone release by GCs at the highest doses (50 μg/mL of RSV with 5000 ng/mL of DON). On the other hand, the stimulatory effect of RSV in combination with DON was significantly (P < 0.05) lower in comparison with alone DON effect. In conclusion, our results indicate, (1) the dose-depended stimulatory effects of RSV, DON and combination of RSV with DON on release of steroid hormone progesterone and (2) reduction of the stimulatory effect of DON by RSV. Our in vitro results suggest that reproductive toxicity of animals induced by a mycotoxin - deoxynivalenol can be inhibited by a protective natural substance - resveratrol. |
| | |
Authors:
|
Adriana Kolesarova; Marcela Capcarova; Nora Maruniakova; Norbert Lukac; Renata E Ciereszko; Alexander V Sirotkin |
Related Documents
:
|
11409538 - Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (mdi) aerosol i... 18461498 - Bronchodilating effect and anabolic effect of inhaled procaterol. 22418458 - Ventilatory threshold during incremental running can be estimated using emg shorts. 22748108 - Pharmacokinetic analysis of ziconotide (snx-111), an intrathecal n-type calcium channel... 16498858 - Onset of action of a topical antihistamine as assessed by histamine challenge-induced p... 18037588 - Postimplantation analysis enables improvement of dose-volume histograms and reduction o... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering Volume: 47 ISSN: 1532-4117 ISO Abbreviation: J Environ Sci Health A Tox Hazard Subst Environ Eng Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-04-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812551 Medline TA: J Environ Sci Health A Tox Hazard Subst Environ Eng Country: England |
Other Details:
|
Languages: eng Pagination: 1329-34 Citation Subset: IM |
Affiliation:
|
a Department of Animal Physiology, Faculty of Biotechnology and Food Sciences , Slovak University of Agriculture in Nitra , Nitra , Slovak Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structural and ultrastructural study of the rabbit testes exposed to carbamate insecticide.
Next Document: Mechanism of phytoestrogen action in Leydig cells of ganders (Anser anser domesticus): Interaction w...