Document Detail

Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation.
MedLine Citation:
PMID:  17052855     Owner:  NLM     Status:  MEDLINE    
The stilbene resveratrol exerts antiproliferative and proapoptotic actions on a number of different cancer cell lines, through diverse mechanisms, including antioxidant effects, enzyme, growth factor and hormone receptor binding, and nucleic acid direct or indirect interactions. Although resveratrol accumulates in the liver, its effect on hepatocellular carcinoma has not been extensively studied. We have used the human hepatocyte-derived cancer cell line HepG2 to address the possible action of resveratrol on cell growth and to examine some possible mechanisms of action. Our results indicate that the stilbene inhibits potently cell proliferation, reduces the production of reactive oxygen species and induces apoptosis, through cell cycle arrest in G1 and G2/M phases. Furthermore it modulates the NO/NOS system, by increasing iNOS and eNOS expression, NOS activity and NO production. Inhibition of NOS enzymes attenuates its antiproliferative effect. These data could be of value in possible prevention or adjuvant treatment of hepatocellular carcinoma, through an increased consumption of resveratrol-rich foods and beverages.
George Notas; Artemissia-Phoebe Nifli; Marilena Kampa; Joseph Vercauteren; Elias Kouroumalis; Elias Castanas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-22
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1760     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-01-09     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1657-66     Citation Subset:  IM    
Laboratories of Gastroenterology, University of Crete School of Medicine, Heraklion, Greece.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Carcinoma, Hepatocellular / metabolism*
Cell Cycle / drug effects*
Cell Proliferation / drug effects
G1 Phase
G2 Phase
Liver Neoplasms / metabolism*
Nitric Oxide / metabolism
Nitric Oxide Synthase / metabolism*
Reactive Oxygen Species / metabolism
Stilbenes / pharmacology*
Time Factors
Transcription, Genetic
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Reactive Oxygen Species; 0/Stilbenes; 10102-43-9/Nitric Oxide; EC Oxide Synthase; Q369O8926L/resveratrol

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