| Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation. | |
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MedLine Citation:
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PMID: 17052855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stilbene resveratrol exerts antiproliferative and proapoptotic actions on a number of different cancer cell lines, through diverse mechanisms, including antioxidant effects, enzyme, growth factor and hormone receptor binding, and nucleic acid direct or indirect interactions. Although resveratrol accumulates in the liver, its effect on hepatocellular carcinoma has not been extensively studied. We have used the human hepatocyte-derived cancer cell line HepG2 to address the possible action of resveratrol on cell growth and to examine some possible mechanisms of action. Our results indicate that the stilbene inhibits potently cell proliferation, reduces the production of reactive oxygen species and induces apoptosis, through cell cycle arrest in G1 and G2/M phases. Furthermore it modulates the NO/NOS system, by increasing iNOS and eNOS expression, NOS activity and NO production. Inhibition of NOS enzymes attenuates its antiproliferative effect. These data could be of value in possible prevention or adjuvant treatment of hepatocellular carcinoma, through an increased consumption of resveratrol-rich foods and beverages. |
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Authors:
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George Notas; Artemissia-Phoebe Nifli; Marilena Kampa; Joseph Vercauteren; Elias Kouroumalis; Elias Castanas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-22 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1760 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-07 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1657-66 Citation Subset: IM |
Affiliation:
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Laboratories of Gastroenterology, University of Crete School of Medicine, Heraklion, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology* Apoptosis / drug effects Carcinoma, Hepatocellular / metabolism* Cell Cycle / drug effects* Cell Proliferation / drug effects G1 Phase G2 Phase Humans Liver Neoplasms / metabolism* Nitric Oxide / metabolism Nitric Oxide Synthase / metabolism* Reactive Oxygen Species / metabolism Stilbenes / pharmacology* Time Factors Transcription, Genetic Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Reactive Oxygen Species; 0/Stilbenes; 10102-43-9/Nitric Oxide; 501-36-0/resveratrol; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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