Document Detail


Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells.
MedLine Citation:
PMID:  19827268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol (trans-3,4', 5-trihydroxystilbene) is a naturally occurring polyphenolic compound that has antiinflammatory, antioxidant, neuroprotective properties and acts as a chemopreventive agent. Resveratrol causes cell cycle arrest and induces apoptotic cell death in various types of cancer cells. In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol decreased both the expression and phosphorylation of Akt. Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced LDH release and caspase-3 activation. Resveratrol reduced phosphorylation of ribosomal protein S6 and the mTOR inhibitor rapamycin further enhanced resveratrol-induced cell death. These results suggest that the downregulation of PI3K/Akt/mTOR signaling pathways may be an important mediator in resveratrol-induced apoptosis in glioma cells.
Authors:
Hao Jiang; Xia Shang; Hongtao Wu; Subhash C Gautam; Shaza Al-Holou; Christina Li; Jarret Kuo; Lijie Zhang; Michael Chopp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of experimental therapeutics & oncology     Volume:  8     ISSN:  1359-4117     ISO Abbreviation:  J. Exp. Ther. Oncol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-10-27     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9604933     Medline TA:  J Exp Ther Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Affiliation:
Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA. hjiang1@hfhs.org
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Caspase 3 / metabolism
Cell Line, Tumor
Cyclin D1 / antagonists & inhibitors
Dose-Response Relationship, Drug
Down-Regulation
Glioma / drug therapy*,  pathology
Humans
Phosphatidylinositol 3-Kinases / antagonists & inhibitors*
Protein Kinases / drug effects*
Proto-Oncogene Proteins c-akt / antagonists & inhibitors*
Signal Transduction / drug effects*
Stilbenes / pharmacology*
TOR Serine-Threonine Kinases
Grant Support
ID/Acronym/Agency:
R21 AT003463-01A2/AT/NCCAM NIH HHS; R21 AT003463-01A2/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/CCND1 protein, human; 0/Stilbenes; 136601-57-5/Cyclin D1; EC 2.7.-/Protein Kinases; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 3.4.22.-/Caspase 3; Q369O8926L/resveratrol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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