| Resveratrol dietary supplementation shortens the free-running circadian period and decreases body temperature in a prosimian primate. | |
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MedLine Citation:
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PMID: 21628554 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Resveratrol (RSV) is a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. We tested the effect of RSV on the circadian clock in a nonhuman primate, the gray mouse lemur. The impact of a 2-week dietary supplementation of RSV on the rhythms of locomotor activity and body temperature in constant dark conditions (DD) was investigated in young (n = 7) and old (n = 6) animals. RSV supplementation followed 2 weeks in DD under normal diet (CTL). In both young and old animals receiving RSV, we observed a shortening of the free-running period compared to those under CTL (-15 minutes in young animals and -45 minutes in old animals), accompanied by a lower mean body temperature in both age groups and decreased locomotor activity in young animals. Thus, RSV is a food component capable of influencing a primate's circadian clock. This property may be of interest clinically in the context of the treatment of circadian disruption and in the context of the effects of RSV ingestion on health. |
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Authors:
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Fabien Pifferi; Alexandre Dal-Pan; Michael Menaker; Fabienne Aujard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biological rhythms Volume: 26 ISSN: 1552-4531 ISO Abbreviation: J. Biol. Rhythms Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: United States |
Other Details:
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Languages: eng Pagination: 271-5 Citation Subset: IM |
Affiliation:
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UMR CNRS-MNHN 7179, Brunoy, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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