Document Detail


Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines.
MedLine Citation:
PMID:  20521268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol, which is highly concentrated in the skin of grapes and is abundant in red wine, has been demonstrated to account for several beneficial properties, including antioxidant, anticoagulant, anti-inflammatory and anticancer effects. Taxol is a microtubule-stabilizing drug that has been extensively used as effective chemotherapeutic agents in the treatment of solid tumors. Here, we investigated whether the combination of the two compounds would yield increased antitumor efficacy in human cancer cells. Unexpectedly, resveratrol effectively prevented tumor cell death induced by taxol in 5637 bladder cancer cells. This pronounced antagonistic function of resveratrol against taxol was associated with changes in multiple signal transduction pathways, but not with tubulin polymerization. Importantly, cell cycle analysis showed that resveratrol prevented the cells from entering into mitosis, the phase in which taxol exerts its action. Furthermore, resveratrol blocked the cytotoxic effects of vinblastine but not cisplatin in 5637 cells. Interestingly, resveratrol pre-treatment followed by taxol resulted in synergistic cytotoxicity. Finally, we extended our studies to various human cancer cell lines. Taken together, our results indicate that resveratrol may have the potential to negate the therapeutic efficacy of taxol and suggest that consumption of resveratrol-related products may be contraindicated during cancer therapy with taxol.
Authors:
Qi-Qi Mao; Yu Bai; Yi-Wei Lin; Xiang-Yi Zheng; Jie Qin; Kai Yang; Li-Ping Xie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  54     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-04     Completed Date:  2011-02-17     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1574-84     Citation Subset:  IM    
Affiliation:
Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis*
Cell Cycle / drug effects*
Cell Line, Tumor
Cisplatin / pharmacology
Humans
Mitosis / drug effects
Paclitaxel / antagonists & inhibitors*
Polymerization
Signal Transduction
Stilbenes / pharmacology*
Vinblastine / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Stilbenes; 15663-27-1/Cisplatin; 33069-62-4/Paclitaxel; 865-21-4/Vinblastine; Q369O8926L/resveratrol

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