| Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 22231915 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Resveratrol protects the cardiovascular system by a number of mechanisms, including antioxidant and anti-platelet activities. OBJECTIVE: To assess the potential anti-inflammatory and antiatherogenic effects of resveratrol using rabbits fed a hypercholesterolemic diet (1% cholesterol). METHODS: Twenty white male rabbits were selected and divided into two groups: control group (CG), 10 rabbits; and resveratrol group (RG), 10 rabbits. The animals were fed a hypercholesterolemic diet for 56 days. For the RG diet, resveratrol (2mg/kg weight/day) was added from days 33 - 56. RESULTS: There was no significant difference in the total serum cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides between the groups. Of the CG, 70% had advanced aortic atherosclerotic lesions (types III, IV, V, or VI). All animals from the RG had mild aortic atherosclerotic lesions (types I or II, or no lesions). The intima area and the intima/media layer area ratio was significantly lower in the RG as compared to the CG (p<0.001). Positive areas for VCAM-1 molecules were lower in the RG (p=0.007). The MCP-1 and IL-6 concentrations were lower in the RG than the CG (p=0.039 and p=0.015, respectively). CONCLUSION: Resveratrol had significant anti-atherogenic and anti-inflammatory effects in an animal model with rabbits fed a hypercholesterolemic diet (1% cholesterol). |
| | |
Authors:
|
Rossane Serafim Matos; Lis Andréa Villela Baroncini; Leonardo Brandão Précoma; Guilherme Winter; Pedro Henrique Lambach; Caron; Flávia Kaiber; Dalton Bertolim Précoma |
Related Documents
:
|
3893165 - Effects of adrenalectomy on energy balance of obese mice are diet dependent. 7815175 - A dietary nucleoside-nucleotide mixture inhibits endotoxin-induced bacterial translocat... 1464745 - Effects of dietary fat on cholesterol movement between tissues in cba/j and c57br/cdj m... 19008465 - Deficiency of growth differentiation factor 3 protects against diet-induced obesity by ... 15924935 - Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations ... 19460655 - Improving diet and physical activity with alive: a worksite randomized trial. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-09 |
Journal Detail:
|
Title: Arquivos brasileiros de cardiologia Volume: - ISSN: 1678-4170 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: - |
Other Details:
|
Languages: ENG; POR Pagination: - Citation Subset: - |
Affiliation:
|
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil. |
Vernacular Title:
|
Resveratrol provoca efeitos antiaterogênicos em um modelo animal de aterosclerose. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.
Next Document: Anthropometric measures as predictors of cardiovascular disease risk factors in the urban population...