Document Detail

Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  10885794     Owner:  NLM     Status:  MEDLINE    
We examined the effect of resveratrol (3,4',5-trihydroxy stilbene), a phenolic compound found in the skins of most grapes, on blood pressure and bone loss in ovariectomized (OVX), stroke-prone spontaneously hypertensive rats (SHRSP). Nineteen-week-old female SHRSP were divided into a sham-ovariectomized (sham) group fed a control diet and two OVX groups fed either a control diet (OVX-Cont) or a diet supplemented with resveratrol (5 mg/kg per d; OVX-Resv). Ovariectomy induced significant increases in systolic blood pressure (SBP). Resveratrol lowered the SBP by 15%) by the third week of administration, and this effect was maintained throughout the study. Resveratrol treatment also significantly enhanced endothelium-dependent vascular relaxation in response to acetylcholine (ACh) in OVX rats. Finally, femur breaking energies measured for the resveratrol-treated (OVX-Resv) group were significantly higher than those of the resveratrol-untreated (OVX-Cont) group. While no significant differences in calcium, magnesium and phosphorus content were found between the femurs of OVX-Cont and OVX-Resv rats, the femur hydroxyproline content in the OVX-Resv group was significantly higher than of the OVX-Cont group. We conclude that, in OVX-SHRSP, resveratrol acts by a similar mechanism to mammalian estrogens, lowering blood pressure by increasing dilatory responses to ACh. The present study also demonstrated that resveratrol was able to prevent ovariectomy-induced decreases in femoral bone strength.
K Mizutani; K Ikeda; Y Kawai; Y Yamori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  46     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use
Bone Density / drug effects*
Disease Models, Animal
Femur / drug effects,  physiology
Hypertension / drug therapy*,  etiology
Osteoporosis / etiology,  prevention & control*
Rats, Inbred SHR
Stilbenes / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Stilbenes; Q369O8926L/resveratrol

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