| Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 10885794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of resveratrol (3,4',5-trihydroxy stilbene), a phenolic compound found in the skins of most grapes, on blood pressure and bone loss in ovariectomized (OVX), stroke-prone spontaneously hypertensive rats (SHRSP). Nineteen-week-old female SHRSP were divided into a sham-ovariectomized (sham) group fed a control diet and two OVX groups fed either a control diet (OVX-Cont) or a diet supplemented with resveratrol (5 mg/kg per d; OVX-Resv). Ovariectomy induced significant increases in systolic blood pressure (SBP). Resveratrol lowered the SBP by 15%) by the third week of administration, and this effect was maintained throughout the study. Resveratrol treatment also significantly enhanced endothelium-dependent vascular relaxation in response to acetylcholine (ACh) in OVX rats. Finally, femur breaking energies measured for the resveratrol-treated (OVX-Resv) group were significantly higher than those of the resveratrol-untreated (OVX-Cont) group. While no significant differences in calcium, magnesium and phosphorus content were found between the femurs of OVX-Cont and OVX-Resv rats, the femur hydroxyproline content in the OVX-Resv group was significantly higher than of the OVX-Cont group. We conclude that, in OVX-SHRSP, resveratrol acts by a similar mechanism to mammalian estrogens, lowering blood pressure by increasing dilatory responses to ACh. The present study also demonstrated that resveratrol was able to prevent ovariectomy-induced decreases in femoral bone strength. |
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Authors:
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K Mizutani; K Ikeda; Y Kawai; Y Yamori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 46 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-09-14 Completed Date: 2000-09-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Affiliation:
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Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology, therapeutic use Bone Density / drug effects* Disease Models, Animal Female Femur / drug effects, physiology Hypertension / drug therapy*, etiology Osteoporosis / etiology, prevention & control* Ovariectomy* Rats Rats, Inbred SHR Stilbenes / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Stilbenes; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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