| Resveratrol is absorbed in the small intestine as resveratrol glucuronide. | |
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MedLine Citation:
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PMID: 10872829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied the absorption and metabolism of resveratrol in the jejunum in an isolated rat small intestine model. Only small amounts of resveratrol were absorbed across the enterocytes of the jejunum and ileum unmetabolised. The major compound detected on the serosal side was the glucuronide conjugate of resveratrol (96.5% +/- 4.6 of the amount absorbed) indicating the susceptibility of resveratrol to glucuronidation during transfer across the rat jejunum. The presence of the glucuronide was confirmed using HPLC-PDA and nanoES-MS/MS techniques. These findings suggest that resveratrol is most likely to be in the form of a glucuronide conjugate after crossing the small intestine and entering the blood circulation. This will have important implications for the biological functions of resveratrol in vivo. |
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Authors:
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G Kuhnle; J P Spencer; G Chowrimootoo; H Schroeter; E S Debnam; S K Srai; C Rice-Evans; U Hahn |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 272 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-07-17 Completed Date: 2000-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Leipzig, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / chemistry, pharmacokinetics* Biological Transport, Active Glucuronides / chemistry, pharmacokinetics Ileum / metabolism Intestinal Absorption Intestine, Small / metabolism* Jejunum / metabolism Kinetics Male Perfusion Rats Rats, Sprague-Dawley Stilbenes / chemistry, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Glucuronides; 0/Stilbenes; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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