| Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes. | |
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MedLine Citation:
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PMID: 20872255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The SIRT1 enzyme is involved in adipose tissue (AT) lipolysis. FOXO1 is a protein that plays a significant role in regulating metabolism. Adiponectin is an adipokine, secreted by the AT, which has been considered to have an antiobesity function. PPARγ is one of the key actors in adipocytes differentiation. This study was undertaken to investigate whether resveratrol can regulate SIRT1, FOXO1, adiponectin, PPARγ1-3, and PPARβ/δ in human AT. METHODS: The effects of resveratrol were analyzed in freshly isolated adipocytes prepared from visceral fat tissue samples obtained during bariatric surgery. Genes messenger ribonucleic acid (mRNA) levels were determined by qRT-PCR. RESULTS: Ours results show that resveratrol modulates the studied genes, increasing SIRT1 (p = 0.021), FOXO1 (p = 0.001), and adiponectin (p = 0.025) mRNA expression and decreasing PPARγ1-3 (p = 0.003) mRNA in human visceral adipocytes. CONCLUSIONS: Resveratrol, in vitro and at low concentration, modulates genes that are related to lipid metabolism, possibly preventing metabolic disease in human visceral adipose tissue (VAT). |
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Authors:
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Cíntia dos Santos Costa; Francieli Rohden; Thais Ortiz Hammes; Rogério Margis; Josiane Woutheres Bortolotto; Alexandre Vontobel Padoin; Cláudio Cora Mottin; Regina Maria Guaragna |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obesity surgery Volume: 21 ISSN: 1708-0428 ISO Abbreviation: Obes Surg Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-18 Completed Date: 2011-06-30 Revised Date: 2013-06-03 |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: United States |
Other Details:
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Languages: eng Pagination: 356-61 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos 2600 Anexo, 90035-003, Porto Alegre, RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism* Adiponectin / genetics, metabolism* Adult Down-Regulation / drug effects Forkhead Transcription Factors / genetics, metabolism* Gene Expression Regulation / drug effects Humans Intra-Abdominal Fat / cytology Lipid Metabolism / drug effects* Lipid Regulating Agents / pharmacology* Obesity, Morbid / genetics, metabolism*, surgery PPAR gamma / genetics, metabolism* RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Sirtuin 1 / genetics, metabolism* Stilbenes / pharmacology* Up-Regulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Lipid Regulating Agents; 0/PPAR gamma; 0/RNA, Messenger; 0/Stilbenes; EC 3.5.1.-/SIRT1 protein, human; EC 3.5.1.-/Sirtuin 1; Q369O8926L/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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