| Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits. | |
| | |
MedLine Citation:
|
PMID: 20676927 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: Resveratrol has been shown to have vasoprotective effects by upregulating oxidative defense mechanisms in a variety of pathophysiological conditions. However, the effect of resveratrol on diabetic oxidative stress and vascular and metabolic abnormalities is not completely understood. Therefore, this study was designed to evaluate whether long-term resveratrol supplementation has a protective effect on vascular function and integrity in association with metabolic parameters and oxidative stress in insulin-dependent diabetes. METHODS: Diabetes was induced in rabbits with alloxan and maintained for 8 weeks. We used a resveratrol dose of 5 mg/L (10 weeks, starting 14 days before alloxan injection) and 50 mg/L (8 or 10 weeks, starting concomitantly or 14 days before alloxan injection) in the drinking water of rabbits. RESULTS: Relaxation to acetylcholine was impaired (control 75.6 ± 3.59%, versus diabetic 42.23 ± 2.53%) and contractions to phenylephrine increased (control 136.89 ± 2.27%, versus diabetic 159.37 ± 6.27%) in aortas from diabetic animals. These changes were associated with increased basal or NAD(P)H-induced superoxide production, as well as lipid peroxide and superoxide dismutase (SOD) levels in the aortic samples. The maximal relaxation to acetylcholine improved by 75.74 ± 9.04% in diabetic rabbits treated with resveratrol. The increased contractions to phenylephrine were not restored to control values after resveratrol treatments, but sensitivity to the contractions tended to decrease. Resveratrol increased nitrite/nitrate levels and suppressed basal or NAD(P)H-induced superoxide production and lipid peroxide levels in the aortas. Importantly, resveratrol increased serum insulin levels without affecting blood glucose and the lipid profile in diabetic rabbits. Using electron microscopic examinations, resveratrol was found to markedly protect the endothelial integrity from diabetes. CONCLUSION: Overall, there was no noticeable difference between resveratrol treatment groups on the recovery from diabetes. Our results indicate that resveratrol alleviates type 1 diabetes-induced vasculopathy by decreasing vascular oxidative stress and thereby increasing the bioavailability of nitric oxide without changing metabolic abnormalities. |
| | |
Authors:
|
Fatma Akar; M Bilgehan Pektas; Can Tufan; Selen Soylemez; Aylin Sepici; A Tulga Ulus; Burcu Gokalp; Kamile Ozturk; H Selcuk Surucu |
Related Documents
:
|
20723007 - Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. 2121567 - Effect of insulin on oxidation of intracellularly and extracellularly derived glucose i... 21864017 - Performance of the roche accu-chek active glucose meter to screen for gestational diabe... 12011047 - Involvement of c-jun n-terminal kinase in oxidative stress-mediated suppression of insu... 12756307 - Neurogenic positional pedal neuritis. common pedal manifestations of spinal stenosis. 17389257 - Previous hypertensive disease of pregnancy is associated with alterations of markers of... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 25 ISSN: 1573-7241 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 119-31 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey, fakar@gazi.edu.tr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aldosterone inhibition and cardiovascular protection: more important than it once appeared.
Next Document: Peer navigation improves diagnostic follow-up after breast cancer screening among Korean American wo...