| Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programmed by neonatal protein restriction. | |
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MedLine Citation:
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PMID: 20870710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resveratrol (Res) has been associated with protective effects against oxidative stress. This study evaluated the effect of Res over lipid peroxidation, antioxidant defense, hepatic sirtuin 1 (SIRT1), which up-regulates antioxidant enzymes, and copper/zinc superoxide dismutase (Cu/Zn SOD) in adult offspring whose mothers were protein restricted during lactation. Lactating Wistar rats were divided into control (C) group, which were fed a normal diet (23% protein), and low-protein and high-carbohydrate (LPHC) group, which were fed a diet containing 8% protein. After weaning (21 days), C and LPHC offspring were fed a normal diet until they were 180 days old. At the 160th day, animals were separated into four groups as follows: control, control+Res, LPHC, and LPHC+Res. Resveratrol was given for 20 days (30 mg/kg per day by gavage). LPHC animals showed a higher total antioxidant capacity (TAC) without change in lipid peroxidation and SIRT1 expression. The treatment with Res increased TAC only in the control group without effect on lipid peroxidation and SIRT1. LPHC animals treated with Res had lower lipid peroxidation and higher protein and mRNA expression of SIRT1 without any further increase in TAC. No significant difference in liver Cu/Zn SOD expression was observed among the groups. In conclusion, maternal protein restriction during lactation programs the offspring for a higher antioxidant capacity, and these animals seem to respond to Res treatment with a lower lipid peroxidation and higher hepatic SIRT1 expression that we did not observe in the Res-treated controls. It is probable that the protective effect can be attributed to Res activating SIRT1, only in the LPHC-programmed group. |
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Authors:
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Juliana Gastão Franco; Egberto Gaspar de Moura; Josely Correa Koury; Paula Affonso Trotta; Aline Cordeiro; Luana Lopes Souza; Norma Aparecida dos Santos Almeida; Natália da Silva Lima; Carmen Cabanelas Pazos-Moura; Patrícia Cristina Lisboa; Magna Cottini Fonseca Passos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-24 |
Journal Detail:
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Title: The Journal of endocrinology Volume: 207 ISSN: 1479-6805 ISO Abbreviation: J. Endocrinol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 319-28 Citation Subset: IM |
Affiliation:
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Department of Physiological Sciences, Roberto Alcântara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-030, RJ, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Antioxidants / analysis, pharmacology* Blood Glucose / drug effects Diet, Protein-Restricted* Female Insulin / blood Insulin Resistance / physiology Lipid Peroxidation / drug effects* Lipids / blood Liver / drug effects, enzymology Male Rats Rats, Wistar Sirtuin 1 / analysis, metabolism* Stilbenes / pharmacology* Superoxide Dismutase / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 0/Lipids; 0/Stilbenes; 11061-68-0/Insulin; 501-36-0/resveratrol; EC 1.15.1.1/Superoxide Dismutase; EC 3.5.1.-/Sirtuin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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