Document Detail


Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome.
MedLine Citation:
PMID:  22867714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Resveratrol has been shown to reverse some of the detrimental effects of metabolic syndrome (MetS). We sought to define the impact of supplemental resveratrol on normal myocardium remote from an ischemic territory in a swine model of MetS and chronic myocardial ischemia.
STUDY DESIGN: Yorkshire swine were fed a normal diet (control), a high cholesterol diet (HCD), or a high cholesterol diet with orally supplemented resveratrol (HCD-R; 100 mg/kg/day). Four weeks after diet modification, myocardial ischemia was induced by ameroid constrictor placement. Seven weeks later, myocardial tissue from a territory remote from the ischemia was harvested. Animals in the HCD and HCD-R groups underwent functional cardiac MRI before ischemia and before sacrifice. Tissue was harvested for protein expression analysis.
RESULTS: After 7 weeks of ischemia, regional left ventricular systolic function was significantly increased in HCD-R as compared with HCD animals. During ventricular pacing the HCD group had significantly decreased flow (p = 0.03); perfusion in the HCD-R was preserved as compared with the control. There was no difference in microvascular relaxation. Expression of metabolic proteins Sirt-1 (p = 0.002), AMPkinase (p = 0.02), and carnitine palmitoyltransferase-I (p = 0.002) were upregulated in the HCD-R group. Levels of protein oxidative stress were significantly increased in the HCD and HCD-R groups, as compared with the controls (p = 0.003). Activated endothelial nitric oxide synthase (eNOS) was increased in the HCD-R group (p = 0.01). There was no difference in myocardial endothelial cell density between the groups; however, dividing endothelial cells were decreased in the HCD and HCD-R groups (p = 0.006).
CONCLUSIONS: Resveratrol supplementation improves regional left ventricular function and preserves perfusion to myocardium remote from an area of ischemia in an animal model of metabolic syndrome and chronic myocardial ischemia.
Authors:
Michael P Robich; Louis M Chu; Thomas A Burgess; Jun Feng; Yuchi Han; Reza Nezafat; Michael P Leber; Roger J Laham; Warren J Manning; Frank W Sellke
Related Documents :
12514644 - Noncompaction of the ventricular myocardium: the use of contrast-enhanced echocardiogra...
21843584 - Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple ...
22508054 - Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant p...
22433654 - Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induce...
23430664 - Omega-3 in antiarrhythmic therapy : pros position.
11309724 - The role of integrated myocardial management in reoperative coronary surgery.
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-04
Journal Detail:
Title:  Journal of the American College of Surgeons     Volume:  215     ISSN:  1879-1190     ISO Abbreviation:  J. Am. Coll. Surg.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2012-12-27     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9431305     Medline TA:  J Am Coll Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology,  therapeutic use*
Biological Markers / metabolism
Blotting, Western
Coronary Vessels / drug effects*
Diet, High-Fat
Disease Models, Animal
Fluorescent Antibody Technique
Heart
Magnetic Resonance Imaging
Metabolic Syndrome X / complications,  drug therapy*
Myocardial Ischemia / etiology
Myocardium / metabolism
Oxidative Stress
Stilbenes / pharmacology,  therapeutic use*
Swine
Ventricular Function, Left / drug effects*
Grant Support
ID/Acronym/Agency:
5T32-HL0074/HL/NHLBI NIH HHS; 5T32-HL007734-19/HL/NHLBI NIH HHS; 5T32-HL094300/HL/NHLBI NIH HHS; R01 EB008743/EB/NIBIB NIH HHS; R01 HL046716/HL/NHLBI NIH HHS; R01 HL069024/HL/NHLBI NIH HHS; R01 HL085647/HL/NHLBI NIH HHS; R01HL46716/HL/NHLBI NIH HHS; R01HL69024/HL/NHLBI NIH HHS; T32 HL007734/HL/NHLBI NIH HHS; T32 HL076130/HL/NHLBI NIH HHS; T32 HL094300/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Stilbenes; Q369O8926L/resveratrol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.
Next Document:  Design and Initial Implementation of HerQLes: A Hernia-Related Quality-of-Life Survey to Assess Abdo...